Exclusive Bitter Receptors Screening Service
- Determine the potency and efficacy drugs, drug products, and reference compounds against the 22 human TAS2R bitterness receptors
- Host cells have been constructed that contain a clone of the receptor, the coupling G-protein, and a fluorescent reporter.
- Binding of a bitter compound to a TAS2R leads to activation of the signal transduction pathway and an increase in fluorescence, enabling generation of dose-response data.
- Available to test per API per receptor for response as well as testing against proprietary antagonists